Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.74 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.74 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.74 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.74 |
| ▸ | ADORA2A | P29274 | 8/20 | 0.74 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.69 |
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | TPO | P07202 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3699117 | 0.91 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7602847 | 0.85 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL9791629 | 0.83 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Enprofylline SCHEMBL156402 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| Enprofylline SCHEMBL1817246 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL5515323 | 0.81 | ADORA2A (0.71) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL10360644 | 0.80 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL7466316 | 0.78 | ADORA2A (1.00) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL383123 | 0.78 | ADORA2A (0.72) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL19370607 | 0.77 | PDE4A (0.64) | PDE4APDE4BPDE4CPDE4DADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116492457-A | Lowering systemic regulatory T cell levels or activity for treatment of diseases and injuries of the central nervous system | 耶达研究与开发有限公司 | 2023-07-28 | — | — | CN | disclosed |
| CN-108348607-B | Lowering systemic regulatory T cell levels or activity for treatment of diseases and injuries of the central nervous system | 耶达研究与开发有限公司 | 2023-06-23 | — | — | CN | disclosed |