Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 1.00 |
| ▸ | ADORA2A | P29274 | 11/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 11/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 11/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 11/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.83 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.83 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.83 |
| ▸ | BLM | P54132 | 1/20 | 0.83 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.83 |
| ▸ | PNP | P00491 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.56 |
| ▸ | BRD2 | P25440 | 1/20 | 0.56 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.56 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791629 | 0.94 | PDE4A (0.89) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| Enprofylline SCHEMBL1817246 | 0.91 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| Enprofylline SCHEMBL156402 | 0.91 | PDE4A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL1460898 | 0.86 | PDE4A (0.75) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL9032157 | 0.86 | PDE4A (0.75) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL30488609 | 0.85 | PDE4A (0.74) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL7466316 | 0.84 | ADORA2A (1.00) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL562981 | 0.82 | PDE4A (0.70) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL562982 | 0.82 | PDE4A (0.70) | PDE4AADORA2APDE4BPDE4CPDE4D | |
| SCHEMBL3699117 | 0.82 | PDE4A (0.73) | PDE4AADORA2APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5470579-A | Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation | LVMH, RECHERCHE (FR) | 1995-11-28 | — | — | US | claimed |
| EP-0502043-B1 | UTILIZATION OF XANTHINES, OPTIONALLY INCORPORATED IN LIPOSOMES IN ORDER TO HELP THE PIGMENTATION OF SKIN OR HAIR | LVMH RECH (FR) | 1995-03-01 | — | — | EP | claimed |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2022-01-18 | — | — | US | disclosed |
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2019-09-26 | — | — | US | disclosed |
| EP-0812844-B1 | Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof | HOECHST AG (DE) | 2002-10-23 | — | — | EP | disclosed |
| US-6221874-B1 | 7-CYCLIC-SUBSTITUTED SULFONYL-3,7-DIHYDRO-PURINE-2, 6-DIONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION | 2001-04-24 | — | — | US | disclosed |
| US-6214992-B1 | THEOPHYLLINE DERIVATIVES HAVING AT LEAST ONE ETHER FUNCTION IN METHYL RADICAL; XANTHINE COMPOUNDS WITH THIS SUBSTITUTION PATTERN USED AS ANTISHOCK TREATMENT | HOECHST AKTIENGESELLSCHAFT (DE) | 2001-04-10 | — | — | US | disclosed |
| EP-0812844-A2 | Use of theophyllin derivatives for the treatment and prophylaxis fo shock conditions, novel xanthine compounds and processes for the production thereof | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-12-17 | — | — | EP | disclosed |
| EP-0502043-B1 | UTILIZATION OF XANTHINES, OPTIONALLY INCORPORATED IN LIPOSOMES IN ORDER TO HELP THE PIGMENTATION OF SKIN OR HAIR | LVMH RECH (FR) | 1995-03-01 | — | — | EP | disclosed |
| EP-0042706-B1 | XANTHINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A PROCESS FOR THEIR PREPARATION | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1985-12-27 | — | — | EP | disclosed |
| EP-0157098-A1 | Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation | Beecham Wuelfing GmbH & Co KG (DE) | 1985-10-09 | — | — | EP | disclosed |
| US-4372959-A | TREATMENT OF PERIPHERAL VASCULAR DISEASE | BEECHAM-WULFING GMBH & CO. KG (DE) | 1983-02-08 | — | — | US | disclosed |
| EP-0042706-A2 | Xanthine derivatives, pharmaceutical compositions containing them and a process for their preparation | BEECHAM - WUELFING GmbH & Co. KG (DE) | 1981-12-30 | — | — | EP | disclosed |
| US-4289776-A | VASODILATORS, FIBRINOLYTIC | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | disclosed |
| US-4242345-A | VASODILATORS | Wulfing, Johann A. (DE) | 1980-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292186-A1 | XANTHINE DERIVATIVE INHIBITORS OF BET PROTEINS | BET1, BRD4, BRD3 | PDE4A 1873/4885ADORA2A 3171/4885PDE4B 1806/4885 |
| US-11225481-B2 | Xanthine derivative inhibitors of BET proteins | BET1, BRD4, BRD3 | PDE4A 1873/4885ADORA2A 3171/4885PDE4B 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.