Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 7/20 | 0.39 |
| ▸ | MMP2 | P08253 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13308063 | 0.83 | RAB9A (0.48) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL2932315 | 0.81 | RAB9A (0.49) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL23146142 | 0.78 | HPGD (0.50) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL23146098 | 0.77 | RAB9A (0.45) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL30112780 | 0.75 | DAO (0.56) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL30489160 | 0.72 | FGFR1 (0.48) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL30489144 | 0.72 | KDM4E (0.46) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL1244790 | 0.70 | RAB9A (0.50) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL1242490 | 0.70 | DAO (0.60) | RAB9AKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6625289 | 0.70 | ALDH1A1 (0.52) | RAB9AKDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107787322-B | Tricyclic compounds and their use as phosphodiesterase inhibitors | 辉瑞大药厂 | 2023-07-07 | — | — | CN | disclosed |