Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NNMT | P40261 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30112008 | 0.90 | HCAR2 (0.42) | SIRT6TSHRHCAR2KDM4EALDH1A1 | |
| SCHEMBL19555767 | 0.90 | HCAR2 (0.42) | SIRT6TSHRHCAR2KDM4EALDH1A1 | |
| SCHEMBL25804805 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1MAPTKMT2A | |
| SCHEMBL29684052 | 0.78 | SIRT6 (0.50) | SIRT6TSHRADORA3MC4RADRA1A | |
| SCHEMBL19645365 | 0.75 | SIRT6 (0.67) | SIRT6TSHRADORA3MC4RADRA1A | |
| SCHEMBL5047018 | 0.75 | SIRT6 (0.47) | SIRT6TSHRADORA3MC4RADRA1A | |
| SCHEMBL27730675 | 0.74 | SIRT6 (0.51) | SIRT6KDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL2793061 | 0.74 | SIRT6 (0.47) | SIRT6ADRA1AHCAR3 | |
| SCHEMBL2635320 | 0.72 | SIRT6 (0.73) | SIRT6TSHRADORA3MC4RADRA1A | |
| SCHEMBL4697005 | 0.71 | SIRT6 (0.55) | SIRT6TSHRADORA3MC4RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452456-B1 | BICYCLIC MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2023-07-05 | — | — | EP | disclosed |