Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25289842 | 1.00 | GLS (0.46) | GLSEPHX2CYP3A4HDAC3HDAC1 | |
| SCHEMBL24675764 | 0.95 | GLS (0.47) | GLSEPHX2CYP3A4HDAC3HDAC1 | |
| SCHEMBL24675795 | 0.95 | GLS (0.47) | GLSEPHX2CYP3A4HDAC3HDAC1 | |
| SCHEMBL24675890 | 0.91 | GLS (0.45) | GLSEPHX2CYP3A4HDAC3HDAC1 | |
| SCHEMBL25256244 | 0.90 | CNR1 (0.45) | CYP3A4CNR2CNR1CA12CA1 | |
| SCHEMBL30490842 | 0.87 | GLS (0.43) | GLSEPHX2CYP3A4FAAHCA12 | |
| SCHEMBL25249150 | 0.87 | GLS (0.43) | GLSEPHX2CYP3A4FAAHCA12 | |
| SCHEMBL24675927 | 0.86 | GLS (0.44) | GLSEPHX2CYP3A4FAAHCA12 | |
| SCHEMBL24675183 | 0.83 | ROCK2 (0.49) | GLSEPHX2CYP3A4CNR2FAAH | |
| SCHEMBL24675514 | 0.82 | CA12 (0.41) | HDAC8CNR2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A9 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |