Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 8/20 | 0.46 |
| ▸ | GRM5 | P41594 | 7/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12740696 | 0.89 | GRM1 (0.54) | GPR119GRM1GRM5TNK2PDK4 | |
| SCHEMBL12740695 | 0.86 | GPR119 (0.61) | GPR119HPGDSKDM4EMAPTTHRB | |
| SCHEMBL31736656 | 0.84 | GRM1 (0.51) | GRM1GRM5TNK2JAK1PDK4 | |
| SCHEMBL15756310 | 0.83 | GRM1 (0.55) | GPR119GRM1GRM5TNK2PDK4 | |
| SCHEMBL18009522 | 0.79 | GRM1 (0.53) | GPR119GRM1GRM5TNK2PDK4 | |
| SCHEMBL29138576 | 0.79 | GRM1 (0.53) | GPR119GRM1GRM5TNK2PDK4 | |
| SCHEMBL64701 | 0.79 | GRM1 (0.55) | GPR119GRM1GRM5TNK2PDK4 | |
| SCHEMBL27167704 | 0.79 | GRM1 (0.53) | GRM1GRM5TNK2PDK4CYP11B2 | |
| SCHEMBL15756312 | 0.79 | GRM1 (0.59) | GPR119GRM1GRM5PDK4PDE10A | |
| SCHEMBL15001430 | 0.78 | GRM1 (0.52) | GPR119GRM1GRM5PDK4CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466260-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | Astrazeneca AB (SE) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023139199-A1 | COMPOUNDS AND THEIR USE IN TREATING CANCER | ASTRAZENECA AB (SE) | 2023-07-27 | — | — | WO | disclosed |