Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25360538 | 1.00 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL25361244 | 0.86 | KDM4E (0.38) | ADORA2AADORA1ADORA3CYP3A4KDM4E | |
| SCHEMBL30858003 | 0.86 | KDM4E (0.38) | ADORA2AADORA1ADORA3CYP3A4KDM4E | |
| SCHEMBL30494909 | 0.86 | ADORA2B (0.43) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL25359782 | 0.86 | ADORA2B (0.43) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL30690334 | 0.82 | EGFR (0.37) | — | |
| SCHEMBL25360145 | 0.82 | DHODH (0.41) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL25360382 | 0.81 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL25360386 | 0.81 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 | |
| SCHEMBL30495001 | 0.81 | ADORA2A (0.39) | ADORA2AADORA2BADORA1ADORA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159155-A1 | INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) AND USES THEREOF | PIVALENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |