Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 14/20 | 0.63 |
| ▸ | CTSB | P07858 | 5/20 | 0.52 |
| ▸ | CTSS | P25774 | 1/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29076336 | 1.00 | CTSK (0.63) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL25310395 | 1.00 | CTSK (0.63) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL29076334 | 1.00 | CTSK (0.63) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL25310404 | 1.00 | CTSK (0.63) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL25307530 | 0.90 | CTSB (0.52) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL30497441 | 0.90 | CTSB (0.52) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL29076218 | 0.90 | CTSB (0.52) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL25307535 | 0.90 | CTSB (0.52) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL29076214 | 0.90 | CTSB (0.52) | CTSKCTSBCTSSBAZ2BMAPT | |
| SCHEMBL30497438 | 0.88 | CTSK (0.61) | CTSKCTSBCTSSBAZ2BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118742549-A | Cathepsin K inhibitor, preparation method and application thereof | 山东新时代药业有限公司 | 2024-10-01 | — | — | CN | claimed |
| CN-116514804-A | Cathepsin K inhibitor, preparation method and application thereof | 山东新时代药业有限公司 | 2023-08-01 | — | — | CN | claimed |
| CN-118742549-A | Cathepsin K inhibitor, preparation method and application thereof | 山东新时代药业有限公司 | 2024-10-01 | — | — | CN | disclosed |
| CN-116514804-A | Cathepsin K inhibitor, preparation method and application thereof | 山东新时代药业有限公司 | 2023-08-01 | — | — | CN | disclosed |