SCHEMBL305008

SCHEMBL305008

O=[N+]([O-])c1ccc2c(c1)NCCO2

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.54
ALDH1A1 P00352 2/20 0.54
GAA P10253 1/20 0.54
HSD17B10 Q99714 1/20 0.54
MEN1 O00255 5/20 0.46
KMT2A Q03164 5/20 0.46
PDE3B Q13370 2/20 0.44
PDE3A Q14432 2/20 0.44
RAB9A P51151 6/20 0.43
NPC1 O15118 5/20 0.43
SMN1; SMN2 Q16637 4/20 0.43
LMNA P02545 3/20 0.43
MAPK1 P28482 1/20 0.43
BRD4 O60885 1/20 0.40
CRHBP P24387 1/20 0.40
CRHR2 Q13324 1/20 0.40
HPGD P15428 1/20 0.40
BAZ1A Q9NRL2 1/20 0.40
ADRA2A P08913 1/20 0.40
PNMT P11086 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31021148 1.00 MAPT (0.54) MAPTALDH1A1GAAHSD17B10MEN1
Hydrochloric Acid SCHEMBL3115146 0.98 MAPT (0.53) MAPTALDH1A1GAAHSD17B10MEN1
SCHEMBL31035910 0.91 MAPT (0.44) MAPTALDH1A1GAAHSD17B10MEN1
SCHEMBL2062223 0.91 MAPT (0.44) MAPTALDH1A1GAAHSD17B10MEN1
SCHEMBL303351 0.87 MEN1 (0.46) MAPTALDH1A1GAAHSD17B10MEN1
SCHEMBL31021147 0.87 MEN1 (0.46) MAPTALDH1A1GAAHSD17B10MEN1
SCHEMBL2721900 0.83 MAPT (0.48) MAPTALDH1A1HSD17B10MEN1KMT2A
SCHEMBL2061429 0.80 FABP6 (0.60) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL30781501 0.80 FABP6 (0.60) MAPTALDH1A1MEN1KMT2ARAB9A
SCHEMBL27758385 0.79 MAPT (0.50) MAPTALDH1A1GAAHSD17B10MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122094941-A Novel azido formation of 6-hydroxy-benzomorpholine (3, 4-dihydro-2H-1, 4-benzoxazin-6-ol) 2026-05-26 CN claimed
WO-2025099111-A1 NEW TELESCOPING SYNTHESES OF 6-HYDROXY-BENZOMORPHOLINE (3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL) WELLA GERMANY GMBH (DE) 2025-05-15 WO claimed
CN-112724349-A Novel polymers and uses thereof 立邦涂料(中国)有限公司 2021-04-30 CN claimed
CN-122094941-A Novel azido formation of 6-hydroxy-benzomorpholine (3, 4-dihydro-2H-1, 4-benzoxazin-6-ol) 2026-05-26 CN disclosed
WO-2025137303-A1 META-PHENYLENEDIAMINE ANTIDEGRADANT COMPOUNDS AND USES THEREOF FLEXSYS AMERICA L.P. (US) 2025-06-26 WO disclosed
WO-2025099111-A1 NEW TELESCOPING SYNTHESES OF 6-HYDROXY-BENZOMORPHOLINE (3,4-DIHYDRO-2H-1,4-BENZOXAZIN-6-OL) WELLA GERMANY GMBH (DE) 2025-05-15 WO disclosed
CN-112724349-B Polymer and use thereof 立邦涂料(中国)有限公司 2024-07-05 CN disclosed
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS CURADEV PHARMA PVT. LTD. (IN) 2023-04-20 US disclosed
US-11542492-B2 Ligand-directed covalent modification of protein CELGENE CAR LLC (BM) 2023-01-03 US disclosed
US-11530180-B2 Alpha-5 beta-1 inhibitors THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-12-20 US disclosed
CN-115348861-A Alpha-5 beta-1 inhibitors 加利福尼亚大学董事会 2022-11-15 CN disclosed
US-5391758-A Leukotriene antagonists ZENECA, INC. (US) 1995-02-21 US disclosed
US-5338734-A Leukotriene antagonist properties; antiinflammatory agents ZENECA INC. (US) 1994-08-16 US disclosed
US-5179112-A Leukotriene antagonist as antiallergens and antiinflammatory agents ICI AMERICAS INC. (US) 1993-01-12 US disclosed
CN-1017425-B Process for preparing heterocyclic amide derivatives ICI AMERICA INC (US) 1992-07-15 CN disclosed
EP-0199543-B1 HETEROCYCLIC AMIDE DERIVATIVES ICI AMERICAS INC. (US) 1991-12-04 EP disclosed
US-5030643-A Antiallergens, antiinflammatory agents ICI AMERICAS INC. (US) 1991-07-09 US disclosed
US-4859692-A Heterocyclic amide derivatives and pharmaceutical use ICI AMERICAS INC. (US) 1989-08-22 US disclosed
CN-86103278-A The method for preparing heterocyclic amide derivative 1986-12-17 CN disclosed
EP-0199543-A2 Heterocyclic amide derivatives ICI AMERICAS INC. (US) 1986-10-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11542492-B2 Ligand-directed covalent modification of protein PTMS, SPR, DNPEP MAPT 2032/4885ALDH1A1 719/4885GAA 354/4885
US-20230124361-A1 SMALL MOLECULE STING ANTAGONISTS STING1, CGAS, MAVS MAPT 3716/4885ALDH1A1 3672/4885GAA 864/4885
US-11530180-B2 Alpha-5 beta-1 inhibitors SCN5A, PSMA5, API5 MAPT 2177/4885ALDH1A1 227/4885GAA 174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.