Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BCL3 | P20749 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20598509 | 1.00 | IRAK4 (0.46) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL20598665 | 0.86 | PIM1 (0.47) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL30501459 | 0.86 | PIM1 (0.47) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL30501377 | 0.86 | PIM1 (0.47) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL20598210 | 0.86 | PIM1 (0.47) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL20598114 | 0.85 | WDR5 (0.44) | IRAK4PIM1PIM3MAPTWDR5 | |
| SCHEMBL20597967 | 0.84 | IRAK4 (0.66) | IRAK4PIM1PIM3WDR5 | |
| SCHEMBL30501451 | 0.82 | PIM1 (0.45) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL20598264 | 0.82 | PIM1 (0.45) | IRAK4PIM1PIM3MAPTMAPK10 | |
| SCHEMBL20598571 | 0.82 | CYP1A2 (0.55) | MAPTMAPK10ALDH1A1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032642-B | Kinase inhibitors and methods of making and using the same | 里格尔药品股份有限公司 | 2023-07-18 | — | — | CN | disclosed |