Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 15/20 | 0.64 |
| ▸ | AURKA | O14965 | 12/20 | 0.64 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30423102 | 0.90 | AURKA (0.54) | RPS6KB1AURKAIRAK4JAK3EGFR | |
| SCHEMBL31065080 | 0.90 | AURKA (0.54) | RPS6KB1AURKAIRAK4JAK3EGFR | |
| SCHEMBL30423056 | 0.89 | RPS6KB1 (0.54) | RPS6KB1AURKAIRAK4JAK3AURKB | |
| SCHEMBL29922290 | 0.80 | RPS6KB1 (0.56) | RPS6KB1AURKAIRAK4JAK3AURKB | |
| SCHEMBL666544 | 0.78 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL666204 | 0.78 | RPS6KB1 (1.00) | RPS6KB1AURKAAURKB | |
| SCHEMBL13734933 | 0.74 | SYK (0.66) | RPS6KB1AURKAAURKBEGFR | |
| SCHEMBL30873293 | 0.73 | MAPK8 (0.47) | RPS6KB1AURKAIRAK4AURKB | |
| SCHEMBL28450154 | 0.73 | MAPK8 (0.47) | RPS6KB1AURKAIRAK4AURKB | |
| SCHEMBL3712006 | 0.73 | RPS6KB1 (0.63) | RPS6KB1AURKAIRAK4JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111527084-B | Isofuranone compounds useful as HPK1 inhibitors | 百时美施贵宝公司 | 2023-07-18 | — | — | CN | disclosed |