Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 16/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 14/20 | 0.55 |
| ▸ | PGR | P06401 | 12/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL303972 | 1.00 | NR3C1 (0.55) | NR3C1NR3C2PGRARMEN1 | |
| SCHEMBL305023 | 1.00 | NR3C1 (0.55) | NR3C1NR3C2PGRARMEN1 | |
| SCHEMBL1493940 | 0.79 | NR3C1 (0.65) | NR3C1NR3C2PGRAR | |
| SCHEMBL303654 | 0.78 | NR3C1 (0.64) | NR3C1NR3C2PGRAR | |
| SCHEMBL304124 | 0.78 | NR3C1 (0.64) | NR3C1NR3C2PGRAR | |
| SCHEMBL4404839 | 0.75 | MEN1 (0.46) | MEN1KMT2AHDAC4HDAC6 | |
| SCHEMBL3688817 | 0.75 | NR3C1 (0.59) | NR3C1NR3C2PGRAR | |
| SCHEMBL1931613 | 0.74 | NR3C1 (0.75) | NR3C1NR3C2PGRAR | |
| SCHEMBL5518578 | 0.74 | NR3C1 (0.64) | NR3C1NR3C2PGRAR | |
| SCHEMBL303344 | 0.72 | NR3C1 (0.53) | NR3C1NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869003-B1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2013-05-15 | — | — | EP | disclosed |
| US-8093281-B2 | Indazoles as glucocorticoid receptor ligands | GLAXO GROUP LIMITED (GB) | 2012-01-10 | — | — | US | disclosed |
| US-20090074675-A1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090074675-A1 | INDAZOLES AS GLUCOCORTICOID RECEPTOR LIGANDS | NR3C1, NR3C2, MC2R | NR3C1 1/4885NR3C2 2/4885PGR 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.