Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | IP6K1 | Q92551 | 8/20 | 0.40 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.39 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25316319 | 1.00 | SIGMAR1 (0.41) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL30506786 | 1.00 | SIGMAR1 (0.41) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL25316061 | 1.00 | SIGMAR1 (0.41) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL25315580 | 0.87 | OPRM1 (0.42) | HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL25315584 | 0.87 | OPRM1 (0.42) | HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL30507169 | 0.85 | IP6K1 (0.38) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL30506736 | 0.85 | IP6K1 (0.38) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL25319229 | 0.85 | IP6K1 (0.38) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL25319232 | 0.85 | IP6K1 (0.38) | SIGMAR1IP6K1IP6K3IP6K2PGR | |
| SCHEMBL26024806 | 0.85 | IP6K1 (0.38) | SIGMAR1IP6K1IP6K3IP6K2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024249254-A2 | METHODS OF USING APOL1 INHIBITORS | MAZE THERAPEUTICS, INC. (US) | 2024-12-05 | — | — | WO | disclosed |
| EP-4465982-A2 | APOL1 INHIBITORS AND METHODS OF USE | Maze Therapeutics, Inc. (US) | 2024-11-27 | — | — | EP | disclosed |
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |