Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.42 |
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 4/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 4/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.37 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | MERTK | Q12866 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29042039 | 1.00 | IRAK4 (0.45) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL30508252 | 0.90 | GSK3B (0.40) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL29041964 | 0.89 | IRAK4 (0.48) | IRAK4BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL30508232 | 0.89 | IRAK4 (0.48) | IRAK4BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL29042053 | 0.88 | IRAK4 (0.42) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL30508229 | 0.88 | IRAK4 (0.42) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL30508326 | 0.88 | IRAK4 (0.42) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL29042061 | 0.83 | BMPR1B (0.43) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL30508219 | 0.83 | BMPR1B (0.43) | IRAK4GSK3BDYRK1AWNT1BMPR1B | |
| SCHEMBL30508339 | 0.77 | MET (0.44) | IRAK4BMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116478145-B | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2024-02-02 | — | — | CN | disclosed |
| CN-116478145-A | ALK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-07-25 | — | — | CN | disclosed |