Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | RPA1 | P27694 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25378868 | 1.00 | GPR35 (0.51) | GPR35PTK2PBRM1LDHAIDO1 | |
| SCHEMBL29818393 | 0.77 | PTK2 (0.50) | GPR35PTK2PBRM1LDHAIDO1 | |
| SCHEMBL25194689 | 0.77 | PTK2 (0.50) | GPR35PTK2PBRM1LDHAIDO1 | |
| SCHEMBL10289055 | 0.76 | GPR35 (0.48) | GPR35PTK2PBRM1ATMMEN1 | |
| SCHEMBL20265528 | 0.70 | PTK2 (0.50) | GPR35PTK2PBRM1ATM | |
| SCHEMBL29895393 | 0.69 | ALDH1A1 (0.65) | GPR35PTK2PBRM1LDHAIDO1 | |
| SCHEMBL29225681 | 0.68 | GPR35 (0.66) | GPR35PBRM1ATMMEN1ALDH1A1 | |
| SCHEMBL25256300 | 0.68 | IDO1 (0.66) | GPR35PBRM1LDHAIDO1ATM | |
| SCHEMBL20552533 | 0.68 | GPR35 (1.00) | GPR35PTK2PBRM1IDO1ATM | |
| SCHEMBL4211444 | 0.67 | PTK2 (1.00) | GPR35PTK2PBRM1IDO1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452253-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |