Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25378358 | 1.00 | KCNH2 (0.40) | KCNH2KIF11CTSSCTSKALOX5AP | |
| SCHEMBL26193042 | 0.86 | CYP11B1 (0.40) | KCNH2CYP11B1CYP11B2ALDH1A1MAPT | |
| SCHEMBL30509931 | 0.81 | KIF11 (0.42) | KCNH2KIF11CTSSCTSKALOX5AP | |
| SCHEMBL25378502 | 0.81 | KIF11 (0.42) | KCNH2KIF11CTSSCTSKALOX5AP | |
| SCHEMBL30510138 | 0.77 | KIF11 (0.40) | KCNH2KIF11CTSSCTSKALOX5AP | |
| SCHEMBL25378290 | 0.77 | KIF11 (0.40) | KCNH2KIF11CTSSCTSKALOX5AP | |
| SCHEMBL15729287 | 0.76 | KMT2A (0.46) | ALDH1A1MAPTTDP1SCN4AUSP30 | |
| SCHEMBL25302721 | 0.75 | KCNH2 (0.44) | KCNH2KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL30510039 | 0.75 | KCNH2 (0.44) | KCNH2KIF11GABRA1GABRG2GABRB3 | |
| SCHEMBL2629316 | 0.73 | KEAP1 (0.58) | KCNH2KIF11SCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452253-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | The Katholieke Universiteit Leuven (BE) | 2024-10-30 | — | — | EP | disclosed |
| WO-2023122780-A9 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-11-30 | — | — | WO | disclosed |
| WO-2023122780-A2 | 2-PYRAZOLE ANILINES AND RELATED ANALOGS FOR INHIBITING YAP/TAZ-TEAD | THE KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2023-06-29 | — | — | WO | disclosed |