Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | LCAT | P04180 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25263476 | 1.00 | PARP1 (0.50) | PARP1MAPTCYP2C9CYP2C19GAA | |
| SCHEMBL25309971 | 0.98 | PARP1 (0.49) | PARP1MAPTCYP2C9CYP2C19GAA | |
| SCHEMBL30510765 | 0.98 | PARP1 (0.49) | PARP1MAPTCYP2C9CYP2C19GAA | |
| SCHEMBL30510760 | 0.91 | PARP1 (0.44) | PARP1MAPTSMN1; SMN2LCAT | |
| SCHEMBL25306468 | 0.91 | PARP1 (0.44) | PARP1MAPTSMN1; SMN2LCAT | |
| SCHEMBL25309986 | 0.87 | PARP1 (0.48) | PARP1MAPTSMN1; SMN2CHRM4 | |
| SCHEMBL30510763 | 0.85 | KMT2A (0.57) | PARP1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25309578 | 0.85 | SPR (0.43) | PARP1MAPTSMN1; SMN2KDM4EHPGD | |
| SCHEMBL25310442 | 0.85 | KMT2A (0.57) | PARP1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL25311971 | 0.83 | KMT2A (0.56) | PARP1MAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |