Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RBP4 | P02753 | 11/20 | 0.37 |
| ▸ | TTR | P02766 | 7/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381045 | 1.00 | RBP4 (0.37) | RBP4TTRFFAR4GPR119GRM2 | |
| SCHEMBL21381046 | 1.00 | RBP4 (0.37) | RBP4TTRFFAR4GPR119GRM2 | |
| SCHEMBL21381029 | 0.86 | GPR119 (0.45) | RBP4TTRFFAR4GPR119 | |
| SCHEMBL21381031 | 0.86 | GPR119 (0.45) | RBP4TTRFFAR4GPR119 | |
| SCHEMBL30510942 | 0.86 | GPR119 (0.45) | RBP4TTRFFAR4GPR119 | |
| SCHEMBL21381015 | 0.83 | GPR119 (0.36) | RBP4TTRFFAR4GPR119 | |
| SCHEMBL21381016 | 0.83 | GPR119 (0.36) | RBP4TTRFFAR4GPR119 | |
| SCHEMBL21380999 | 0.82 | RBP4 (0.36) | RBP4TTRFFAR4GPR119IKBKE | |
| SCHEMBL21380997 | 0.82 | RBP4 (0.36) | RBP4TTRFFAR4GPR119IKBKE | |
| SCHEMBL21381004 | 0.82 | RBP4 (0.36) | RBP4TTRFFAR4GPR119IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3468967-B1 | COMPOUNDS CONTAINING BENZO[D][1,3]OXATHIOLE, BENZO[D][1,3]OXATHIOLE 3-OXIDE OR BENZO[D][1,3]OXATHIOLE 3,3-DIOXIDE AND METHODS/USES THEREOF AS AGONISTS OF G PROTEIN-COUPLED RECEPTOR 119 | PRAMANA PHARMACEUTICALS INC (CA) | 2023-07-26 | — | — | EP | disclosed |