SCHEMBL30516405

SCHEMBL30516405

[2H]c1c([2H])c([2H])c(-c2cc(C=O)cn2S(=O)(=O)c2cccnc2)c(F)c1[2H]

nearest known ligand 0.33

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 2/20 0.33
CYP17A1 P05093 1/20 0.33
CYP21A2 P08686 1/20 0.33
CYP11B1 P15538 1/20 0.33
HDAC1 Q13547 1/20 0.33
POLB P06746 1/20 0.32
NAPRT Q6XQN6 1/20 0.32
HTT P42858 2/20 0.32
SLC40A1 Q9NP59 1/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA4 P43681 1/20 0.32
PTGDR2 Q9Y5Y4 1/20 0.31
KDM4E B2RXH2 1/20 0.31
KMT2A Q03164 1/20 0.31
BRAF P15056 1/20 0.31
CHRM5 P08912 1/20 0.31
ERN1 O75460 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL193905 0.86 CHRNB2 (0.38) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL29558411 0.86 CHRNB2 (0.38) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30903548 0.86 CHRNB2 (0.38) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30903546 0.86 CHRNB2 (0.38) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL29051063 0.86 HDAC1 (0.34) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL29051060 0.86 HDAC1 (0.34) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30516393 0.86 HDAC1 (0.34) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30516406 0.86 HDAC1 (0.34) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30894733 0.85 HDAC1 (0.35) NFE2L2CYP17A1CYP21A2CYP11B1HDAC1
SCHEMBL30516401 0.82 KDM4E (0.37) HDAC1POLBNAPRTHTTCHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108794449-B Synthetic method of deuterated fumaric acid vorofacian metabolite 广东东阳光药业有限公司 2023-08-04 CN disclosed