SCHEMBL305168

SCHEMBL305168

NC(=O)N1C=Cc2ccccc2C1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.43
TSHR P16473 2/20 0.42
LMNA P02545 1/20 0.42
MAPK1 P28482 1/20 0.42
SCN4A P35499 1/20 0.42
SCN5A Q14524 1/20 0.42
SCN9A Q15858 1/20 0.42
HSD17B3 P37058 2/20 0.39
NOTUM Q6P988 2/20 0.36
P2RX4 Q99571 4/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP3A4 P08684 1/20 0.34
MAPT P10636 1/20 0.34
PABPC1 P11940 1/20 0.34
BLM P54132 1/20 0.34
DPP9 Q86TI2 2/20 0.33
DPP7 Q9UHL4 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29493257 1.00 HDAC3 (0.43) HDAC3TSHRLMNAMAPK1SCN4A
Hydrochloric Acid SCHEMBL7008280 0.98 HDAC3 (0.42) HDAC3TSHRLMNAMAPK1SCN4A
SCHEMBL304994 0.84 HDAC3 (0.43) HDAC3TSHRHSD17B3NOTUMP2RX4
SCHEMBL29950507 0.84 HDAC3 (0.43) HDAC3TSHRHSD17B3NOTUMP2RX4
SCHEMBL27872842 0.84 HDAC3 (0.43) HDAC3TSHRLMNAMAPK1SCN4A
SCHEMBL19284121 0.83 TSHR (0.40) HDAC3TSHRLMNAMAPK1SCN4A
Hydrochloric Acid SCHEMBL7007436 0.82 HDAC3 (0.43) HDAC3TSHRHSD17B3NOTUMP2RX4
SCHEMBL30014867 0.82 HDAC3 (0.43) HDAC3TSHRLMNAMAPK1SCN4A
SCHEMBL6168375 0.82 HSD17B3 (0.49) HDAC3HSD17B3NOTUMP2RX4MEN1
SCHEMBL4425411 0.82 HDAC3 (0.43) HDAC3TSHRLMNAMAPK1SCN4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023165591-A1 COMPOUNDS AND THEIR USES AS LPAR5 ANTAGONISTS IMMUTHER PHARMATECH (SHANGHAI) CO., LTD. (CN) 2023-09-07 WO claimed
CN-108727416-A The miscellaneous aroma system amide derivatives of tricyclic and its preparation and use 北京大学 2018-11-02 CN claimed
CN-106459071-A New tricyclic quinone derivative 波士顿生物技术公司 2017-02-22 CN claimed
JP-2012500853-A 2012-01-12 JP claimed
EP-2328871-A2 HEDGEHOG PATHWAY MODULATORS IRM LLC (BM) 2011-06-08 EP claimed
WO-2010027746-A2 HEDGEHOG PATHWAY MODULATORS IRM LLC (BM) 2010-03-11 WO claimed
WO-2004019933-A1 METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS PHARMACIA & UPJOHN COMPANY (US) 2004-03-11 WO claimed
WO-2023174383-A1 DIHYDROISOQUINOLINE COMPOUND AND MEDICAL USE THEREOF 中国科学院上海药物研究所 2023-09-21 WO disclosed
WO-2023165591-A1 COMPOUNDS AND THEIR USES AS LPAR5 ANTAGONISTS IMMUTHER PHARMATECH (SHANGHAI) CO., LTD. (CN) 2023-09-07 WO disclosed
CN-110467629-B Benzoquinone derivative, pharmaceutical composition and application thereof 上海迪诺医药科技有限公司 2022-04-08 CN disclosed
EP-3890829-A1 PHARMACEUTICAL COMPOUNDS AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) Almac Discovery Limited (GB) 2021-10-13 EP disclosed
EP-3746432-A1 4-HYDROXYPIPERIDINE DERIVATIVES AND THEIR USE AS INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 19 (USP19) Almac Discovery Limited (GB) 2020-12-09 EP disclosed
EP-3723753-A1 INHIBITORS OF FIBROBLAST ACTIVATION PROTEIN Praxis Biotech LLC (US) 2020-10-21 EP disclosed
WO-2006135723-A2 MODIFIED RELEASE 1-[(3-HYDROXY-ADAMANT-1-YLAMINO)-ACETYL]-PYRROLIDINE-2(S)-CARBONITRILE FORMULATION NOVARTIS AG (CH) 2006-12-21 WO disclosed
CN-1856473-A Isoquinolinone potassium channel inhibitors MERCK & CO INC (US) 2006-11-01 CN disclosed
WO-2004019933-A1 METHOD OF PREVENTING OR TREATING ATHEROSCLEROSIS OR RESTENOSIS PHARMACIA & UPJOHN COMPANY (US) 2004-03-11 WO disclosed
EP-1355886-A1 FUSED HETEROCYCLIC COMPOUNDS Takeda Chemical Industries, Ltd. (JP) 2003-10-29 EP disclosed
WO-2002062764-A9 FUSED HETEROCYCLIC COMPOUNDS TAKEDA CHEMICAL INDUSTRIES LTD (JP) 2002-10-10 WO disclosed
WO-2002062764-A1 FUSED HETEROCYCLIC COMPOUNDS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-08-15 WO disclosed
WO-2002030906-A1 ANTI-TUMOUR COMPOUNDS LA TROBE UNIVERSITY (AU) 2002-04-18 WO disclosed