Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | BLVRB | P30043 | 1/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | CPT1A | P50416 | 1/20 | 0.46 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59273 | 1.00 | NPC1 (0.55) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL60693 | 0.99 | NPC1 (0.54) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL60169 | 0.92 | NPC1 (0.53) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL18950853 | 0.83 | S1PR1 (0.54) | NPC1RAB9AHDAC6CNR2RXFP1 | |
| SCHEMBL25907906 | 0.83 | S1PR1 (0.53) | NPC1RAB9AHDAC6CNR2RXFP1 | |
| SCHEMBL60681 | 0.79 | NPC1 (0.69) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL59247 | 0.77 | RAB9A (0.72) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL60427 | 0.77 | NPC1 (0.76) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL17915624 | 0.76 | KMO (0.59) | NPC1RAB9AL3MBTL1HDAC6MAOA | |
| SCHEMBL60783 | 0.75 | SMN1; SMN2 (0.67) | NPC1RAB9AL3MBTL1HDAC6MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101846-B1 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PTC THERAPEUTICS INC (US) | 2023-08-02 | — | — | EP | disclosed |