Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.65 |
| ▸ | GLA | P06280 | 1/20 | 0.65 |
| ▸ | RECQL | P46063 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.65 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.65 |
| ▸ | TOP1 | P11387 | 3/20 | 0.61 |
| ▸ | TOP2A | P11388 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL25436047 | 1.00 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL24299745 | 0.99 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL24299754 | 0.92 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL16552182 | 0.91 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL22854292 | 0.91 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL25436540 | 0.90 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL23482780 | 0.88 | ALDH1A1 (0.74) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL23191099 | 0.88 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| Trifluoroacetic Acid SCHEMBL29412254 | 0.87 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 | |
| SCHEMBL24299746 | 0.87 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTMEN1SLCO2B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4486924-A2 | NUCLEIC ACID CROSSLINKING REAGENTS AND USES THEREOF | Promega Corporation (US) | 2025-01-08 | — | — | EP | disclosed |
| WO-2023177976-A2 | NUCLEIC ACID CROSSLINKING REAGENTS AND USES THEREOF | PROMEGA CORPORATION (US) | 2023-09-21 | — | — | WO | disclosed |
| EP-4208564-A1 | NUCLEIC ACID MODIFYING REAGENTS AND USES THEREOF | Promega Corporation (US) | 2023-07-12 | — | — | EP | disclosed |