Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.56 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23191099 | 0.97 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL14091141 | 0.96 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL17933710 | 0.93 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL18883256 | 0.93 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| Bromide SCHEMBL25436047 | 0.91 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| Bromide SCHEMBL30522158 | 0.91 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL17933708 | 0.91 | HDAC3 (0.60) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL23191108 | 0.90 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL24299745 | 0.90 | ALDH1A1 (0.66) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL17933707 | 0.90 | HDAC3 (0.59) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002329-A1 | COMPOUNDS AND MODULES FOR INHIBITION OF PRE-miR-21 AND THEIR USE IN TREATMENT OF CERTAIN CANCERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2023-01-05 | — | — | US | disclosed |
| WO-2021087084-A1 | COMPOUNDS AND MODULES FOR INHIBITION OF PRE-miR-21 AND THEIR USE IN TREATMENT OF CERTAIN CANCERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-05-06 | — | — | WO | disclosed |
| EP-3038637-B1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | SCRIPPS RESEARCH INST (US) | 2019-01-16 | — | — | EP | disclosed |
| US-20180089049-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | SCRIPPS RESEARCH INST (US) | 2018-03-29 | — | — | US | disclosed |
| US-20180089049-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | SCRIPPS RESEARCH INST (US) | 2018-03-29 | — | — | US | disclosed |
| US-9795687-B2 | Modularly assembled small molecules for the treatment of myotonic dystrophy type 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-9795687-B2 | Modularly assembled small molecules for the treatment of myotonic dystrophy type 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| US-20160206753-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-07-21 | — | — | US | disclosed |
| US-20160206753-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2016-07-21 | — | — | US | disclosed |
| WO-2015031819-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002329-A1 | COMPOUNDS AND MODULES FOR INHIBITION OF PRE-miR-21 AND THEIR USE IN TREATMENT OF CERTAIN CANCERS | SNRPE, RPRD2, SNRPA | ALDH1A1 2557/4885SMN1; SMN2 2837/4885KDM4E 3300/4885 |
| US-20160206753-A1 | MODULARLY ASSEMBLED SMALL MOLECULES FOR THE TREATMENT OF MYOTONIC DYSTROPHY TYPE 1 | EMG1, HNRNPA1, SNRPE | ALDH1A1 3723/4885SMN1; SMN2 4/4885KDM4E 2001/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.