Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21073 | 0.91 | GRM4 (0.34) | GRM4 | |
| SCHEMBL47762 | 0.86 | CHEK1 (0.38) | GRM4 | |
| SCHEMBL21078 | 0.86 | GRM4 (0.34) | GRM4 | |
| SCHEMBL15006968 | 0.85 | JAK2 (0.31) | — | |
| SCHEMBL15031440 | 0.85 | JAK2 (0.31) | — | |
| SCHEMBL15006969 | 0.85 | JAK2 (0.31) | — | |
| SCHEMBL15007081 | 0.85 | GRM4 (0.34) | GRM4 | |
| SCHEMBL15007380 | 0.81 | GRM4 (0.33) | GRM4 | |
| SCHEMBL15007382 | 0.81 | GRM4 (0.33) | GRM4 | |
| SCHEMBL19684 | 0.81 | GRM4 (0.32) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608668-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |