Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | TTK | P33981 | 3/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21073 | 0.89 | GRM4 (0.34) | CHEK1CCNA2CDK2CCNA1TYK2 | |
| SCHEMBL30524 | 0.86 | GRM4 (0.32) | GRM4 | |
| SCHEMBL21078 | 0.83 | GRM4 (0.34) | CHEK1CCNA2CDK2CCNA1TYK2 | |
| SCHEMBL40556 | 0.83 | HSD17B10 (0.33) | — | |
| SCHEMBL19684 | 0.83 | GRM4 (0.32) | GRM4DGAT1 | |
| SCHEMBL15031440 | 0.82 | JAK2 (0.31) | — | |
| SCHEMBL15006969 | 0.82 | JAK2 (0.31) | — | |
| SCHEMBL15006968 | 0.82 | JAK2 (0.31) | — | |
| SCHEMBL15007081 | 0.82 | GRM4 (0.34) | CHEK1CCNA2CDK2CCNA1TYK2 | |
| SCHEMBL19940 | 0.81 | GRM4 (0.32) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027234-A1 | FUSED TRICYCLIC INHIBITORS OF MAMMALIAN TARGET OF RAPAMYCIN | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |