Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM1A | O60341 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29276560 | 0.75 | MAPT (0.52) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL29276554 | 0.75 | MAPT (0.52) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL15422446 | 0.74 | NPC1 (0.46) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL15422447 | 0.74 | NPC1 (0.46) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL21314868 | 0.73 | ALDH1A1 (0.64) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL15432191 | 0.71 | SMN1; SMN2 (0.40) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL16464446 | 0.71 | LMNA (0.54) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL16464448 | 0.71 | LMNA (0.54) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL15184843 | 0.70 | MAPT (0.51) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA | |
| SCHEMBL7772323 | 0.70 | MAPT (0.51) | MAPTKDM1AALDH1A1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217526-B | Aromatic heterocycle substituted alpha-methylene-gamma-butyrolactone compound, preparation method and application | 西北农林科技大学 | 2024-09-20 | — | — | CN | disclosed |
| CN-116217526-A | Aromatic heterocycle substituted alpha-methylene-gamma-butyrolactone compound, preparation method and application | 西北农林科技大学 | 2023-06-06 | — | — | CN | disclosed |