Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 2/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | STAT5B | P51692 | 1/20 | 0.30 |
| ▸ | PLK4 | O00444 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CHUK | O15111 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18357966 | 0.76 | PDK2 (0.36) | PDK2PDK4CDK1CDK5DYRK1A | |
| SCHEMBL16946863 | 0.73 | DYRK1A (0.37) | PDK2PDK4AURKBAURKAROCK1 | |
| SCHEMBL29723169 | 0.72 | MAPK1 (0.32) | CDK1GSK3AGSK3BCDK5 | |
| Hydrochloric Acid SCHEMBL20529749 | 0.71 | MAPK1 (0.31) | CDK1GSK3AGSK3BCDK5 | |
| Formic Acid SCHEMBL30529490 | 0.70 | — | — | |
| SCHEMBL8459068 | 0.69 | LRRK2 (0.30) | ERBB2CDK2JAK3AURKBPLK4 | |
| SCHEMBL19250873 | 0.69 | MAPK1 (0.34) | PDK2PDK4ERBB2NTRK1 | |
| SCHEMBL25839069 | 0.69 | LRRK2 (0.40) | JAK3JAK2CHUKROCK2ROCK1 | |
| SCHEMBL1617515 | 0.69 | MAPT (0.37) | CHEK1FLT1KDRGSK3AGSK3B | |
| SCHEMBL7576503 | 0.67 | KDM4E (0.34) | JAK3CHEK1FLT1KDRGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117263942-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |