Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18357966 | 0.80 | PDK2 (0.36) | DYRK1APDK2PDK4GAAALDH1A1 | |
| SCHEMBL30988525 | 0.78 | MAPK1 (0.46) | DYRK1AKMT2AGAAAURKAPDPK1 | |
| SCHEMBL1585948 | 0.78 | MAPK1 (0.46) | DYRK1AKMT2AGAAAURKAPDPK1 | |
| SCHEMBL12467739 | 0.77 | DYRK1A (0.37) | DYRK1APDPK1 | |
| SCHEMBL30529350 | 0.73 | PDK2 (0.33) | DYRK1APDK2PDK4AURKAROCK1 | |
| SCHEMBL3504133 | 0.73 | PDK2 (0.38) | PDK2PDK4MAPKAPK2GRM5KMT2A | |
| SCHEMBL16946856 | 0.69 | MAPK1 (0.37) | PDK2PDK4ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14763598 | 0.69 | DYRK1A (0.38) | DYRK1AGAAPDPK1 | |
| SCHEMBL30180924 | 0.69 | DYRK1A (0.38) | DYRK1AGAAPDPK1 | |
| Hydrochloric Acid SCHEMBL30529615 | 0.68 | YTHDC1 (0.41) | GRM5GAAALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017133667-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AND USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA THEREOF | SAVIRA PHARMACEUTICALS GMBH (AT) | 2017-08-10 | — | — | WO | disclosed |
| WO-2015112806-A2 | DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES | TP THERAPEUTICS, INC. (US) | 2015-07-30 | — | — | WO | disclosed |