Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 5/20 | 0.41 |
| ▸ | FPR3 | P25089 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 6/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21383778 | 1.00 | USP30 (0.43) | USP30IDO1FPR2FPR3NAMPT | |
| SCHEMBL23046306 | 0.88 | HDAC2 (0.41) | NAMPTGPR119NPC1RAB9A | |
| SCHEMBL29896962 | 0.87 | GPR119 (0.41) | USP30NAMPTGPR119NPC1RAB9A | |
| SCHEMBL23024100 | 0.87 | GPR119 (0.41) | USP30NAMPTGPR119NPC1RAB9A | |
| SCHEMBL29070186 | 0.86 | PKM (0.43) | NAMPTGPR119NPC1RAB9A | |
| SCHEMBL23046239 | 0.86 | PKM (0.43) | NAMPTGPR119NPC1RAB9A | |
| SCHEMBL30529506 | 0.86 | PKM (0.43) | NAMPTGPR119NPC1RAB9A | |
| SCHEMBL23046133 | 0.85 | TSHR (0.44) | IDO1NAMPTGPR119 | |
| SCHEMBL21383837 | 0.85 | TSHR (0.44) | IDO1NAMPTGPR119 | |
| SCHEMBL29890956 | 0.85 | TSHR (0.44) | IDO1NAMPTGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3768668-B1 | SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS INC (US) | 2024-08-28 | — | — | EP | disclosed |
| CN-117263942-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |