Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30176757 | 0.79 | GRIN1 (0.56) | GRIN1GRIN2BMEN1KMT2ALMNA | |
| SCHEMBL30532165 | 0.78 | GAA (0.46) | KDM4EGAAGRIN1GRIN2BPDE3B | |
| SCHEMBL11223721 | 0.70 | KDM4E (0.51) | KDM4EGAAPDE3BPDE3AMEN1 | |
| SCHEMBL5329685 | 0.70 | KDM4E (0.58) | KDM4EGAAPDE3BPDE3AMEN1 | |
| SCHEMBL31217710 | 0.70 | KDM4E (0.58) | KDM4EGAAPDE3BPDE3AMEN1 | |
| SCHEMBL31397306 | 0.68 | KDM4E (0.44) | KDM4EGAAGRIN1GRIN2BPDE3B | |
| SCHEMBL2268013 | 0.68 | KDM4E (0.59) | KDM4EGAAPDE3BPDE3AMEN1 | |
| SCHEMBL29636037 | 0.67 | GRIN2B (0.54) | GRIN1GRIN2BMEN1KMT2ALMNA | |
| SCHEMBL14609834 | 0.67 | KDM4E (0.58) | KDM4EGAAPDE3BPDE3AMEN1 | |
| SCHEMBL31397203 | 0.66 | PDE3B (0.47) | KDM4EGAAPDE3BPDE3AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3523311-B1 | SUBSTITUTED 1H-IMIDAZO[4,5-B]PYRIDIN-2(3H)-ONES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2023-06-07 | — | — | EP | disclosed |