Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.47 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31397306 | 0.87 | KDM4E (0.44) | PDE3BPDE3AP2RY12KDM4EGAA | |
| SCHEMBL31397447 | 0.77 | PDE3B (0.41) | PDE3BPDE3AP2RY12TLR7CYP4F2 | |
| SCHEMBL11223721 | 0.74 | KDM4E (0.51) | PDE3BPDE3AKDM4EGAAKMT2A | |
| SCHEMBL22493184 | 0.74 | TSHR (0.54) | PDE3BPDE3AP2RY12GAACYP4F2 | |
| SCHEMBL13247054 | 0.70 | LMNA (0.57) | PDE3BPDE3ACYP4F2CYP4A11KMT2A | |
| SCHEMBL23767750 | 0.68 | CYP4F2 (0.47) | KDM4EGAACYP4F2CYP4A11KMT2A | |
| SCHEMBL23582397 | 0.67 | ROCK2 (0.51) | KDM4EGAATLR7CYP4F2CYP4A11 | |
| SCHEMBL2272021 | 0.67 | KDM4E (0.55) | PDE3BPDE3AP2RY12KDM4EGAA | |
| SCHEMBL30532173 | 0.67 | KDM4E (0.43) | PDE3BPDE3AKDM4EGAAKMT2A | |
| SCHEMBL4113212 | 0.67 | CYP4F2 (0.76) | KDM4EGAACYP4F2CYP4A11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | CALICO LIFE SCIENCES LLC (US) | 2024-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240424111-A1 | Degrader Compounds and Uses Thereof | PTPN1, PTPN2, PTPN5 | PDE3B 3780/4885PDE3A 3612/4885P2RY12 2845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.