Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DDRD2HRH1HTR2AHTR2CSLC6A2
The experimentally established mechanism targets of Trimipramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 6/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 0.97 |
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.53 |
| ▸ | DRD2 known ✓ | P14416 | 3/20 | 0.53 |
| ▸ | HTR2A known ✓ | P28223 | 3/20 | 0.53 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.53 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.97 |
| ▸ | LMNA | P02545 | 6/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.97 |
| ▸ | DRD3 | P35462 | 6/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | HTR1A | P08908 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimipramine SCHEMBL7597041 | 1.00 | SLC6A4 (0.97) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL4081184 | 1.00 | SLC6A4 (0.97) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL5494378 | 0.98 | SLC6A4 (1.00) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL29373768 | 0.98 | SLC6A4 (1.00) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL35144 | 0.98 | SLC6A4 (1.00) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL117756 | 0.98 | SLC6A4 (1.00) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL29564386 | 0.90 | SLC6A4 (0.83) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL6511858 | 0.89 | CHRM1 (0.82) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL6511859 | 0.89 | CHRM1 (0.82) | SLC6A4LMNACYP3A4CHRM1ADRA1A | |
| Trimipramine SCHEMBL27536460 | 0.88 | LMNA (0.98) | SLC6A4LMNACYP3A4CHRM1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597126-A | Pharmaceutical composition for preventing or treating cancer comprising CDK4/6 inhibitor and tricyclic antidepressant | 国立癌症中心 | 2024-02-23 | — | — | CN | claimed |
| CN-111491920-B | Antagonists of muscarinic acetylcholine receptor M4 | 范德比尔特大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-111788182-B | Muscarinic acetylcholine receptor M 4 Antagonists of (2) | 范德堡大学 | 2023-09-26 | — | — | CN | disclosed |