Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DDRD2HRH1HTR2AHTR2CSLC6A2
The experimentally established mechanism targets of Trimipramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 7/20 | 1.00 |
| ▸ | SLC6A2 known ✓ | P23975 | 6/20 | 1.00 |
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.54 |
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.54 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.54 |
| ▸ | HTR2C known ✓ | P28335 | 4/20 | 0.54 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 9/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 7/20 | 1.00 |
| ▸ | DRD3 | P35462 | 7/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 6/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | DRD1 | P21728 | 5/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 5/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trimipramine SCHEMBL29373768 | 1.00 | SLC6A4 (1.00) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL35144 | 1.00 | SLC6A4 (1.00) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL117756 | 1.00 | SLC6A4 (1.00) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL4081184 | 0.98 | SLC6A4 (0.97) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL30533075 | 0.98 | SLC6A4 (0.97) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL7597041 | 0.98 | SLC6A4 (0.97) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL29564386 | 0.91 | SLC6A4 (0.83) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL6511858 | 0.90 | CHRM1 (0.82) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| Trimipramine SCHEMBL6511859 | 0.90 | CHRM1 (0.82) | SLC6A4CHRM1ADRA1ADRD3KCNH2 | |
| SCHEMBL2615203 | 0.89 | LMNA (0.80) | SLC6A4CHRM1ADRA1ADRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3191105-A1 | SULFATE SALT SOLUTION LAXATIVE COMPOSITIONS AND METHODS OF USE THEREOF | Braintree Laboratories, Inc. (US) | 2017-07-19 | — | — | EP | disclosed |
| WO-2016040733-A1 | SULFATE SALT SOLUTION LAXATIVE COMPOSITIONS AND METHODS OF USE THEREOF | BRAINTREE LABORATORIES, INC. (US) | 2016-03-17 | — | — | WO | disclosed |
| EP-1737539-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | Warner-Lambert Company LLC (US) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005099823-A1 | THERAPEUTIC COMBINATION FOR TREATMENT OF ALZHEIMERS DISEASE | WARNER-LAMBERT COMPANY LLC (US) | 2005-10-27 | — | — | WO | disclosed |
| US-6060642-A | TRANSGENIC MICE MODELS FOR GENE FUNCTION, WHEREIN THE TRANSGENIC MICE ARE CHARACTERIZED BY HAVING ALTERED SEROTONIN 5-HT6 RECEPTOR GENE FUNCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-05-09 | — | — | US | disclosed |