Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.38 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364313 | 1.00 | HRH3 (0.43) | HRH3SYKPTGS2ALKOGA | |
| SCHEMBL30541646 | 0.90 | PTGS2 (0.38) | HRH3PTGS2PTGS1 | |
| SCHEMBL30541568 | 0.90 | PTGS2 (0.36) | HRH3SYKPTGS2MAP4K1PTGS1 | |
| SCHEMBL25365280 | 0.90 | PTGS2 (0.36) | HRH3SYKPTGS2MAP4K1PTGS1 | |
| SCHEMBL25364262 | 0.90 | PTGS2 (0.38) | HRH3PTGS2PTGS1 | |
| SCHEMBL25365541 | 0.88 | PTGS2 (0.39) | PTGS2PTGS1 | |
| SCHEMBL30541577 | 0.88 | GPR119 (0.39) | PTGS2MAP4K1PTGS1JAK2JAK3 | |
| SCHEMBL25365048 | 0.88 | PTGS2 (0.37) | SYKPTGS2PTGS1 | |
| SCHEMBL25365387 | 0.88 | GPR119 (0.39) | PTGS2MAP4K1PTGS1JAK2JAK3 | |
| SCHEMBL30541569 | 0.88 | PTGS2 (0.37) | SYKPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479407-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023159153-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |