Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHX9 | Q08211 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | PIP4K2A | P48426 | 3/20 | 0.46 |
| ▸ | PIP4K2B | P78356 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25369304 | 1.00 | DHX9 (0.52) | DHX9HPGDNAMPTROCK1PIP4K2A | |
| SCHEMBL25368259 | 0.88 | ROCK1 (0.50) | DHX9HPGDNAMPTROCK1PIP4K2A | |
| SCHEMBL30543946 | 0.88 | DHX9 (0.53) | DHX9HPGDKCNK3HTTKDM4E | |
| SCHEMBL25368280 | 0.88 | DHX9 (0.53) | DHX9HPGDKCNK3HTTKDM4E | |
| SCHEMBL25368447 | 0.86 | HPGD (0.51) | DHX9HPGDKCNK3HTTKDM4E | |
| SCHEMBL25369907 | 0.85 | HPGD (0.56) | DHX9HPGDNAMPTKCNK3KDM4E | |
| SCHEMBL30544073 | 0.85 | NAMPT (0.53) | DHX9NAMPTPIP4K2APIP4K2BKCNK3 | |
| SCHEMBL25366609 | 0.85 | NAMPT (0.53) | DHX9NAMPTPIP4K2APIP4K2BKCNK3 | |
| SCHEMBL25368034 | 0.84 | KMT2A (0.60) | DHX9HPGDKCNK3KCNK9SMN1; SMN2 | |
| SCHEMBL25368657 | 0.83 | HPGD (0.51) | DHX9HPGDNAMPTKCNK3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479380-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |