Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | DHX9 | Q08211 | 1/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.48 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.44 |
| ▸ | BCR | P11274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25366609 | 1.00 | NAMPT (0.53) | NAMPTHTTLMNADHX9PIP4K2A | |
| SCHEMBL25368168 | 0.90 | NAMPT (0.51) | NAMPTHTTLMNADHX9PIP4K2A | |
| SCHEMBL30544037 | 0.85 | DHX9 (0.52) | NAMPTHTTLMNADHX9PIP4K2A | |
| SCHEMBL25369304 | 0.85 | DHX9 (0.52) | NAMPTHTTLMNADHX9PIP4K2A | |
| SCHEMBL30543946 | 0.83 | DHX9 (0.53) | HTTLMNADHX9KCNK3L3MBTL1 | |
| SCHEMBL25368280 | 0.83 | DHX9 (0.53) | HTTLMNADHX9KCNK3L3MBTL1 | |
| SCHEMBL30543890 | 0.82 | ALDH1A1 (0.50) | NAMPTHTTLMNADHX9L3MBTL1 | |
| SCHEMBL25368167 | 0.82 | ALDH1A1 (0.50) | NAMPTHTTLMNADHX9L3MBTL1 | |
| SCHEMBL25368947 | 0.82 | HTT (0.69) | HTTLMNA | |
| SCHEMBL30543863 | 0.82 | HTT (0.69) | HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479380-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | Accent Therapeutics, Inc. (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023158795-A1 | INHIBITORS OF RNA HELICASE DHX9 AND USES THEREOF | ACCENT THERAPEUTICS, INC. (US) | 2023-08-24 | — | — | WO | disclosed |