Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | IDO2 | Q6ZQW0 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | C1S | P09871 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26441692 | 0.86 | HTR3E (0.47) | HTR3AIDO1TDO2IDO2ABL1 | |
| SCHEMBL30544690 | 0.77 | HTR3A (0.52) | HTR3AKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL30544687 | 0.76 | POLB (0.49) | HTR3AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7600934 | 0.73 | BRD4 (0.41) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11607246 | 0.72 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KMT2AMAPT | |
| SCHEMBL16013889 | 0.72 | KMT2A (0.43) | KDM4ENPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL16013953 | 0.72 | CHEK1 (0.44) | KDM4ENPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL2549238 | 0.70 | HTR3A (0.44) | HTR3AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31322053 | 0.70 | HTR3A (0.64) | HTR3AKDM4ENPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29702376 | 0.70 | KAT2B (0.43) | KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635371-A | Polycyclic pyridazinone derivative serving as SOS1 inhibitor, and preparation method and application thereof | 苏州阿尔脉生物科技有限公司 | 2023-08-22 | — | — | CN | disclosed |