SCHEMBL30545136

SCHEMBL30545136

Oc1cc(C(F)(F)F)ccc1-c1cccnc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.56
CNR2 P34972 1/20 0.56
CYP11B1 P15538 6/20 0.55
CYP11B2 P19099 6/20 0.55
NPC1 O15118 1/20 0.51
DGAT1 O75907 1/20 0.50
KCNH2 Q12809 1/20 0.50
NPY5R Q15761 2/20 0.49
ALOX5AP P20292 2/20 0.49
FEN1 P39748 2/20 0.49
S1PR1 P21453 1/20 0.48
KDR P35968 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP17A1 P05093 1/20 0.47
CYP3A4 P08684 1/20 0.47
KIF11 P52732 1/20 0.46
HTR2B P41595 1/20 0.46
HTR6 P50406 1/20 0.46
ERN1 O75460 1/20 0.46
PDK2 Q15119 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14832292 1.00 CNR1 (0.56) CNR1CNR2CYP11B1CYP11B2NPC1
Formic Acid SCHEMBL30412981 0.93 CYP11B1 (0.50) CNR1CNR2CYP11B1CYP11B2NPC1
SCHEMBL5990332 0.89 CYP11B1 (0.51) CNR1CNR2CYP11B1CYP11B2NPC1
SCHEMBL15989428 0.84 CYP11B1 (0.53) CYP11B1CYP11B2NPC1DGAT1KCNH2
SCHEMBL31359600 0.83 CNR1 (0.63) CNR1CNR2CYP11B1CYP11B2NPC1
SCHEMBL15009839 0.81 CYP11B1 (0.50) CYP11B1CYP11B2NPC1DGAT1KCNH2
SCHEMBL9809559 0.80 ALOX5 (0.55) CNR1CNR2ALOX5APFEN1KIF11
SCHEMBL23326178 0.80 CYP11B1 (0.62) CYP11B1CYP11B2NPC1DGAT1KCNH2
SCHEMBL29775352 0.80 CYP11B1 (0.62) CYP11B1CYP11B2NPC1DGAT1KCNH2
SCHEMBL26133012 0.78 IL1B (0.57) CNR1CNR2CYP11B1CYP11B2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116635029-A REV-ERB agonists 圣路易斯大学 2023-08-22 CN disclosed