Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 12/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26907981 | 1.00 | GPR139 (0.41) | GPR139POLBMAPTSMN1; SMN2PLK1 | |
| SCHEMBL29069555 | 1.00 | GPR139 (0.41) | GPR139POLBMAPTSMN1; SMN2PLK1 | |
| SCHEMBL27114611 | 0.82 | CA1 (0.57) | GPR139POLBMAPTSMN1; SMN2MAPK6 | |
| Hydrochloric Acid SCHEMBL26907910 | 0.80 | MAPT (0.41) | MAPTSMN1; SMN2LMNAMAPK6 | |
| Hydrochloric Acid SCHEMBL26907885 | 0.80 | KDM4E (0.42) | GPR139POLBMAPTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL29770007 | 0.80 | KDM4E (0.42) | GPR139POLBMAPTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27115889 | 0.80 | KDM4E (0.42) | GPR139POLBMAPTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL26907872 | 0.77 | SMO (0.40) | POLBMAPTSMN1; SMN2LMNAMAPK6 | |
| Hydrochloric Acid SCHEMBL26907994 | 0.76 | NQO1 (0.41) | GPR139POLBMAPTSMN1; SMN2LMNA | |
| SCHEMBL26907998 | 0.75 | MAPT (0.42) | GPR139POLBMAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116724026-A | Novel benzotriazole derivatives having inhibitory activity against dinucleotide pyrophosphatase-phosphodiesterase and use thereof | 谛希诺生物科技有限公司 | 2023-09-08 | — | — | CN | claimed |
| CN-116724026-A | Novel benzotriazole derivatives having inhibitory activity against dinucleotide pyrophosphatase-phosphodiesterase and use thereof | 谛希诺生物科技有限公司 | 2023-09-08 | — | — | CN | disclosed |