Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amitriptyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 0.94 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.94 |
| ▸ | HRH1 | P35367 | 8/20 | 0.94 |
| ▸ | HTR2B | P41595 | 8/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.94 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.94 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.94 |
| ▸ | DRD2 | P14416 | 6/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.94 |
| ▸ | HTR2A | P28223 | 6/20 | 0.94 |
| ▸ | HTR2C | P28335 | 6/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.94 |
| ▸ | DRD3 | P35462 | 6/20 | 0.94 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.94 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.94 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.94 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.94 |
| ▸ | HTR1A | P08908 | 5/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amitriptyline SCHEMBL29359365 | 0.97 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL7824 | 0.97 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL2877708 | 0.97 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL28299765 | 0.95 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL14937172 | 0.95 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL41079 | 0.95 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL7215255 | 0.95 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL29356807 | 0.95 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL14918734 | 0.94 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL7214653 | 0.88 | SLC6A2 (0.83) | SLC6A2HRH1HTR2BKCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12191133-B2 | Mass spectrometry method for identifying and/or authenticating a sample | ORVINUM AG (CH) | 2025-01-07 | — | — | US | disclosed |
| US-20240148531-A1 | SYSTEMS AND METHODS FOR DETERMINING FAILURE OF INTRAGASTRIC DEVICES | ASCENT PARTNERS FUND LLC | 2024-05-09 | — | — | US | disclosed |
| CN-115006346-B | Method for stabilizing therapeutic agent for mental disease and composition containing amitriptyline | 湖南洞庭药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-114917213-B | Mental disorder therapeutic agent comprising amitriptyline and method for treating mental disorder | 湖南洞庭药业股份有限公司 | 2023-11-21 | — | — | CN | disclosed |
| US-11730619-B2 | Systems and methods for determining failure of intragastric devices | RESHAPE LIFESCIENCES INC. (US) | 2023-08-22 | — | — | US | disclosed |
| CN-115038451-A | Multimodal compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-115003279-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2022-09-02 | — | — | CN | disclosed |
| US-20220199389-A1 | A MASS SPECTROMETRY METHOD FOR IDENTIFYING AND/OR AUTHENTICATING A SAMPLE | ORVINUM AG (CH) | 2022-06-23 | — | — | US | disclosed |
| EP-3966571-A1 | A MASS SPECTROMETRY METHOD FOR IDENTIFYING AND/OR AUTHENTICATING A SAMPLE | Orvinum AG (CH) | 2022-03-16 | — | — | EP | disclosed |
| US-20220039981-A1 | SYSTEMS AND METHODS FOR DETERMINING FAILURE OF INTRAGASTRIC DEVICES | ASCENT PARTNERS FUND LLC | 2022-02-10 | — | — | US | disclosed |
| CN-109157525-A | A kind of amitriptyline hydrochloride tablet agent and preparation method thereof | 湖南洞庭药业股份有限公司 | 2019-01-08 | — | — | CN | disclosed |
| CN-208161212-U | A kind of Chinese herbal medicine intelligent automobile air conditioner filter element | 李强 | 2018-11-30 | — | — | CN | disclosed |
| US-20180116849-A1 | SYSTEMS AND METHODS FOR DETERMINING FAILURE OF INTRAGASTRIC DEVICES | OBALON THERAPEUTICS, INC. | 2018-05-03 | — | — | US | disclosed |
| US-20160310306-A1 | SYSTEMS AND METHODS FOR DETERMINING FAILURE OF INTRAGASTRIC DEVICES | OBALON THERAPEUTICS, INC. | 2016-10-27 | — | — | US | disclosed |
| CN-203860504-U | Mask with Chinese herbal medicine fragrance | UNIV XI AN SCI & TECHNOLOGY | 2014-10-08 | — | — | CN | disclosed |
| CN-101287988-B | Methods and compositions for diagnosis and treatment of influenza | ARBOR VITA CORP | 2012-10-10 | — | — | CN | disclosed |
| CN-101896161-A | Solid formulations of crystalline compounds | PURDUE RESEARCH FOUNDATION | 2010-11-24 | — | — | CN | disclosed |
| US-20100222311-A1 | SOLID FORMULATIONS OF CRYSTALLINE COMPOUNDS | PURDUE RESEARCH FOUNDATION (US) | 2010-09-02 | — | — | US | disclosed |
| EP-2021502-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | Oy Jurilab Ltd (FI) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007128884-A1 | NOVEL GENES AND MARKERS IN TYPE 2 DIABETES AND OBESITY | OY JURILAB LTD (FI) | 2007-11-15 | — | — | WO | disclosed |