Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amitriptyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 1.00 |
| ▸ | HRH1 | P35367 | 8/20 | 1.00 |
| ▸ | HTR2B | P41595 | 8/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 7/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 6/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 6/20 | 1.00 |
| ▸ | DRD2 | P14416 | 6/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 6/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 6/20 | 1.00 |
| ▸ | HTR2A | P28223 | 6/20 | 1.00 |
| ▸ | HTR2C | P28335 | 6/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 6/20 | 1.00 |
| ▸ | DRD3 | P35462 | 6/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 5/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amitriptyline SCHEMBL29359365 | 1.00 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL2877708 | 1.00 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL28299765 | 0.98 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL41079 | 0.98 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL7215255 | 0.98 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL29356807 | 0.98 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL14937172 | 0.98 | SLC6A2 (1.00) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL3055149 | 0.97 | SLC6A2 (0.94) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL14918734 | 0.97 | SLC6A2 (0.97) | SLC6A2HRH1HTR2BKCNH2CHRM2 | |
| Amitriptyline SCHEMBL7214653 | 0.91 | SLC6A2 (0.83) | SLC6A2HRH1HTR2BKCNH2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 56905 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-121774464-B | Intestinal canal stenosis detection device based on bicolor indication and preparation method thereof | BEIJING FRIENDSHIP HOSPITAL, CAPITAL MEDICAL UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| US-20260131089-A1 | DRUG DELIVERY DEVICES AND METHODS FOR ADMINISTERING SUBSTANCES TO A BODY CAVITY BY HETEROGENOUS AEROSOLIZATION FOR TREATMENT OF BINGE-EATING DISORDERS AND/OR OBESITY | APTARGROUP, INC. (US) | 2026-05-14 | — | — | US | claimed |
| US-20260130868-A1 | METHODS FOR TREATING NEURODEVELOPMENTAL DISORDERS VIA ADMINISTRATION OF ORGANIC TRICYCLIC COMPOUNDS | SYNGAP RES FUND (US) | 2026-05-14 | — | — | US | claimed |
| US-12624037-B2 | Method of treating agitation, aggressive behavior, and impulse control disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| US-12624036-B2 | Method of treating post-traumatic stress disorder | INTRA-CELLULAR THERAPIES, INC. (US) | 2026-05-12 | — | — | US | claimed |
| CN-122011194-A | Amitriptyline antibody and kit | 中南大学 | 2026-05-12 | — | — | CN | claimed |
| US-12617809-B2 | Cardioprotective lipid and method of use | SIGNPATH PHARMA, INC. (US) | 2026-05-05 | — | — | US | claimed |
| US-4241550-A | Domical structure composed of symmetric, curved triangular faces | SUMNER JOHN S | 1980-12-30 | — | — | US | claimed |
| US-4177583-A | Orthopedic shoe with forefoot protective guard | CHAPMAN ANDREW W | 1979-12-11 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4146997-A | Domical-type structure | Raptes, M. Ted (US) | 1979-04-03 | — | — | US | claimed |
| US-4092810-A | Domical structure | SUMNER JOHN S | 1978-06-06 | — | — | US | claimed |
| US-4068422-A | Roofing for domical shell structure | SUMNER JOHN S | 1978-01-17 | — | — | US | claimed |
| US-4039377-A | Nuclear boiler | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1977-08-02 | — | — | US | claimed |
| US-3965255-A | DRUG ENCAPSULATED IN OR COATED WITH A SOLVENT MEMBRANE | E. E. ELJIM ECOLOGY LTD. (IL) | 1976-06-22 | — | — | US | claimed |
| US-3962064-A | ELECTROLYZER AND A METHOD FOR THE PRODUCTION OF READILY OXYDIZABLE METALS IN A STATE OF HIGH PURITY | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1976-06-08 | — | — | US | claimed |
| US-3950901-A | Domical structure with novel beam interlocking connections | SUMNER JOHN S | 1976-04-20 | — | — | US | claimed |