Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amitriptyline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 8/20 | 1.00 |
| ▸ | SLC6A4 known ✓ | P31645 | 6/20 | 0.97 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 4/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ATM | Q13315 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 8/20 | 0.97 |
| ▸ | HTR2B | P41595 | 8/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.97 |
| ▸ | DRD2 | P14416 | 6/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.97 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amitriptyline SCHEMBL29356807 | 1.00 | SLC6A2 (1.00) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL14937172 | 1.00 | SLC6A2 (1.00) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL14918734 | 0.98 | SLC6A2 (0.97) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL2877708 | 0.98 | SLC6A2 (1.00) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL7824 | 0.98 | SLC6A2 (1.00) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL29359365 | 0.98 | SLC6A2 (1.00) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL28299765 | 0.97 | SLC6A2 (0.97) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL7215255 | 0.97 | SLC6A2 (0.97) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL3055149 | 0.95 | SLC6A2 (0.94) | SLC6A2LMNAALDH1A1PMP22MEN1 | |
| Amitriptyline SCHEMBL8070446 | 0.90 | SLC6A2 (0.83) | SLC6A2LMNAALDH1A1PMP22MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 9440 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260115166-A1 | COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF PHOTORECEPTOR ROD DEGENERATIONS AND GENERATION OF PHOTORECEPTORS | PURDUE RESEARCH FOUNDATION (US) | 2026-04-30 | — | — | US | claimed |
| EP-4725506-A2 | THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-1-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | Stealth BioTherapeutics Inc. (US) | 2026-04-15 | — | — | EP | claimed |
| EP-4702057-A1 | IN VIVO IMAGING OF AN ALS BIOMARKER AND MEANS THEREFOR | AL-S Pharma AG (CH) | 2026-03-04 | — | — | EP | claimed |
| EP-3986401-B1 | THE PEPTIDOMIMETIC COMPOUND (R)-2-AMINO-N-((S)-L-(((S)-5-AMINO-L-(3-BENZYL-1,2,4-OXADIAZOL-5-YL)PENTYL)AMINO)-3-(4-HYDROXY-2,6-DIMETHYLPHENYL)-1-OXOPROPAN-2-YL)-5-GUANIDINOPENTANAMIDE FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS | STEALTH BIOTHERAPEUTICS INC (US) | 2026-01-28 | — | — | EP | claimed |
| EP-3931189-B1 | AZEPINO-INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | UNIV CALIFORNIA (US) | 2025-12-24 | — | — | EP | claimed |
| US-20250339483-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS THERAPEUTICS SAS (FR) | 2025-11-06 | — | — | US | claimed |
| EP-4608424-A1 | EXTRACELLULAR VESICLES FROM MICROALGAE, THEIR BIODISTRIBUTION UPON INTRANASAL ADMINISTRATION, AND USES THEREOF | AGS Therapeutics SAS (FR) | 2025-09-03 | — | — | EP | claimed |
| US-12337065-B2 | Compositions for treating viral infections and methods for same | ACCESS TO ADVANCED HEALTH INSTITUTE (US) | 2025-06-24 | — | — | US | claimed |
| CN-120148666-A | Cooling-solventing-out coupling crystallization simulation optimization method and system based on Aspen Plus V14 and MATLAB cooperation | 河北工业大学 | 2025-06-13 | — | — | CN | claimed |
| CN-118903008-B | Amitriptyline spray and preparation method and application thereof | 十堰市太和医院（湖北医药学院附属医院） | 2025-06-13 | — | — | CN | claimed |
| WO-1998018610-A1 | EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES | LENGERICH BERNHARD H VAN (US) | 1998-05-07 | — | — | WO | claimed |
| WO-1998015275-A2 | METHOD AND POTENTIATED COMPOSITION FOR TREATING MIGRAINE | ALGOS PHARMACEUTICAL CORPORATION (US) | 1998-04-16 | — | — | WO | claimed |
| EP-0741570-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020387-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1995-08-03 | — | — | WO | claimed |
| US-4977145-A | ADMINISTERING ANGIOTENSIN CONVERTING ENZYME INHIBITOR AND ANTIDEPRESSANT | E. R. SQUIBB & SONS, INC. (US) | 1990-12-11 | — | — | US | claimed |
| US-4788189-A | Method to treat smoking withdrawal symptoms by potentiated central noradrenergic blocking | GLAZER HOWARD I (US) | 1988-11-29 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| US-4505909-A | Method and composition for treating and preventing irritation of the eyes | BERNSTEIN JOEL E (US) | 1985-03-19 | — | — | US | claimed |
| US-4370324-A | Method and composition for treating and preventing irritation of the eyes | BERNSTEIN JOEL E (US) | 1983-01-25 | — | — | US | claimed |
| EP-0048023-A2 | Composition for treating and preventing irritation of the eyes | Bernstein, Joel E., M.D. (US) | 1982-03-24 | — | — | EP | claimed |