SCHEMBL30554205

SCHEMBL30554205

C[C@@H]1CN(c2cc(=O)n(C)c3ccc(C#N)nc23)[C@@H](C)CN1C(c1ccc(F)cn1)c1ccc(F)cc1F

nearest known ligand 0.72

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGKZ Q13574 20/20 0.72
DGKA P23743 19/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21831130 1.00 DGKZ (0.72) DGKZDGKA
SCHEMBL30554449 0.94 DGKZ (0.79) DGKZDGKA
SCHEMBL21830820 0.94 DGKZ (0.79) DGKZDGKA
SCHEMBL25326700 0.94 DGKZ (0.79) DGKZDGKA
SCHEMBL21831369 0.91 DGKZ (0.74) DGKZDGKA
SCHEMBL30554264 0.91 DGKZ (0.74) DGKZDGKA
SCHEMBL21831127 0.91 DGKA (0.85) DGKZDGKA
SCHEMBL30554221 0.91 DGKA (0.85) DGKZDGKA
SCHEMBL21830658 0.89 DGKA (0.78) DGKZDGKA
SCHEMBL21831128 0.89 DGKA (0.78) DGKZDGKA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112654621-B Substituted naphthyridinone compounds useful as T cell activators 百时美施贵宝公司 2024-05-14 CN claimed
EP-3814348-B9 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-11-01 EP claimed
EP-3814348-B1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 EP claimed
CN-112654621-B Substituted naphthyridinone compounds useful as T cell activators 百时美施贵宝公司 2024-05-14 CN disclosed
EP-3814348-B9 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-11-01 EP disclosed
EP-3814348-B1 SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-08-02 EP disclosed