Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 6/20 | 0.39 |
| ▸ | DGKZ | Q13574 | 6/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21911507 | 1.00 | DGKA (0.39) | DGKADGKZKDM4DMAPK14CNR1 | |
| SCHEMBL25329619 | 0.87 | DGKA (0.42) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL21831880 | 0.87 | DGKA (0.42) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL30554480 | 0.86 | DGKA (0.51) | DGKADGKZKDM4DMAPK14HCRTR2 | |
| SCHEMBL25329438 | 0.86 | DGKA (0.51) | DGKADGKZKDM4DMAPK14HCRTR2 | |
| SCHEMBL29922480 | 0.83 | MAPK14 (0.44) | DGKADGKZKDM4DMAPK14TACR1 | |
| SCHEMBL30554491 | 0.83 | MAPK14 (0.44) | DGKADGKZKDM4DMAPK14TACR1 | |
| SCHEMBL29922490 | 0.83 | MAPK14 (0.44) | DGKADGKZKDM4DMAPK14TACR1 | |
| SCHEMBL29922715 | 0.83 | MAPK14 (0.44) | DGKADGKZKDM4DMAPK14TACR1 | |
| SCHEMBL26944415 | 0.83 | MAPK14 (0.44) | DGKADGKZKDM4DMAPK14TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |