Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGKA | P23743 | 12/20 | 0.42 |
| ▸ | DGKZ | Q13574 | 12/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21831880 | 1.00 | DGKA (0.42) | DGKADGKZMAPK14HCRTR2SLC6A9 | |
| SCHEMBL30554398 | 0.87 | DGKA (0.39) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL21911507 | 0.87 | DGKA (0.39) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL21831500 | 0.84 | DGKA (0.55) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL25327774 | 0.84 | DGKA (0.55) | DGKADGKZMAPK14HCRTR2 | |
| SCHEMBL21831278 | 0.81 | MAPK14 (0.48) | DGKADGKZMAPK14SLC6A9DPP8 | |
| SCHEMBL25328436 | 0.81 | MAPK14 (0.48) | DGKADGKZMAPK14SLC6A9DPP8 | |
| SCHEMBL21831485 | 0.81 | MAPK14 (0.48) | DGKADGKZMAPK14SLC6A9DPP8 | |
| SCHEMBL21831860 | 0.81 | MAPK14 (0.48) | DGKADGKZMAPK14SLC6A9DPP8 | |
| SCHEMBL21831294 | 0.79 | SIGMAR1 (0.41) | DGKADGKZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |