Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364691 | 1.00 | CYP2D6 (0.40) | CYP2D6GRM2KCNJ1PTGS2JAK2 | |
| SCHEMBL25364788 | 0.93 | PTGS2 (0.39) | CYP2D6GRM2PTGS2MAOAMAOB | |
| SCHEMBL30557465 | 0.93 | PTGS2 (0.39) | CYP2D6GRM2PTGS2MAOAMAOB | |
| SCHEMBL30557460 | 0.89 | HRH3 (0.37) | GRM2PTGS2JAK2JAK3PTK2 | |
| SCHEMBL25368100 | 0.89 | HRH3 (0.37) | GRM2PTGS2JAK2JAK3PTK2 | |
| SCHEMBL25368054 | 0.87 | GRM2 (0.42) | GRM2KCNJ1PTGS2JAK2JAK3 | |
| SCHEMBL30557471 | 0.87 | GRM2 (0.42) | GRM2KCNJ1PTGS2JAK2JAK3 | |
| SCHEMBL25367392 | 0.84 | GPR119 (0.42) | CYP2D6KCNJ1PTGS2USP2CYP1A2 | |
| SCHEMBL30541576 | 0.84 | GPR119 (0.42) | CYP2D6KCNJ1PTGS2USP2CYP1A2 | |
| SCHEMBL25366146 | 0.82 | HRH3 (0.47) | GRM2PTGS2JAK2JAK3PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479135-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | disclosed |
| CN-118786130-A | Substituted imidazopyridinyl compounds useful as TLR9 inhibitors | 百时美施贵宝公司 | 2024-10-15 | — | — | CN | disclosed |
| WO-2023159154-A9 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-10-10 | — | — | WO | disclosed |
| WO-2023159154-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |