Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20838957 | 1.00 | JAK3 (0.44) | JAK3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30558296 | 0.87 | JAK3 (0.46) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL20839065 | 0.87 | JAK3 (0.46) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL20848279 | 0.86 | JAK3 (0.46) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL24649798 | 0.85 | MEN1 (0.46) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL30516042 | 0.85 | MEN1 (0.46) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL24649800 | 0.85 | JAK3 (0.45) | JAK3RETMAPTMEN1KMT2A | |
| SCHEMBL12557792 | 0.83 | JAK3 (0.48) | JAK3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL20838955 | 0.83 | MAPT (0.49) | JAK3CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30558295 | 0.83 | MAPT (0.49) | JAK3CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111132981-B | Process for preparing pyrido [1,2-A ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116813648-A | Process for preparing 2- (2, 8-dimethylimidazo [1,2-B ] pyridazin-6-yl) pyrido [1,2-a ] pyrimidin-4-one derivatives | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |