Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13162094 | 0.77 | ALDH1A1 (0.50) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL11484185 | 0.71 | MAPT (0.47) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL11489944 | 0.70 | MAPT (0.49) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL2415260 | 0.70 | ALDH1A1 (0.52) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL2753245 | 0.68 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL21393188 | 0.68 | ALDH1A1 (0.59) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL2422709 | 0.68 | ALDH1A1 (0.59) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL2422479 | 0.67 | ALDH1A1 (0.58) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL1267536 | 0.67 | ALDH1A1 (0.58) | ALDH1A1KDM4EL3MBTL1MAPTKMT2A | |
| SCHEMBL4783999 | 0.66 | KDM4E (0.50) | ALDH1A1KDM4EL3MBTL1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229395-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009090054-A1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2009-07-23 | — | — | WO | disclosed |