Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485475 | 0.82 | MAPT (0.60) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL6369627 | 0.81 | MAPT (0.55) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL11489944 | 0.78 | MAPT (0.49) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL13162094 | 0.76 | ALDH1A1 (0.50) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2415260 | 0.75 | ALDH1A1 (0.52) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL3055910 | 0.71 | ALDH1A1 (0.47) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2753245 | 0.70 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2422709 | 0.68 | ALDH1A1 (0.59) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL2421945 | 0.66 | ADRA2C (0.52) | MAPTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL1267065 | 0.65 | ALDH1A1 (0.56) | MAPTKDM4EALDH1A1L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4188389-A | 1,2,3,4-Tetrahydropyrrolo(1,2-A)pyrazines | AYERST MCKENNA & HARRISON, INC. (CA) | 1980-02-12 | — | — | US | disclosed |