Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21570550 | 0.88 | ABL1 (0.57) | ABL1BCRMAPTMEN1KMT2A | |
| SCHEMBL15436240 | 0.77 | EGFR (0.62) | MEN1KMT2ACASP3SENP7KDR | |
| SCHEMBL6402301 | 0.73 | ABL1 (1.00) | ABL1BCRCCNT1CCNE1CDK2 | |
| SCHEMBL11541657 | 0.71 | MEN1 (0.76) | MAPTMEN1KMT2ACASP3SENP7 | |
| SCHEMBL1897213 | 0.71 | KDR (0.80) | KDRTNNI3K | |
| SCHEMBL13472422 | 0.69 | CYP1A2 (0.50) | ABL1BCRMAPTCYP1A2CYP3A4 | |
| SCHEMBL9521235 | 0.68 | CYP3A4 (0.58) | ABL1BCRMAPTCYP1A2CYP3A4 | |
| SCHEMBL1518723 | 0.68 | CNR1 (0.69) | CASP3SENP7CLK4TSHRCDK9 | |
| SCHEMBL374604 | 0.68 | MEN1 (0.66) | MAPTMEN1KMT2AKDRLMNA | |
| SCHEMBL25825682 | 0.68 | TAAR1 (0.85) | MAPTMEN1KMT2ACASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784650-B1 | N-PHENYL-N'-(4-{[6-(1H-IMIDAZOL-1-YL)-4-PYRIMIDINYL]AMINO}PHENYL)UREA DERIVATIVES AS MCT4 INHIBITORS FOR THE TREATMENT OF CANCER | CHARLES R DREW UNIV OF MEDICINE AND SCIENCE (US) | 2023-09-06 | — | — | EP | disclosed |
| EP-3784650-C0 | N-PHENYL-N'-(4-{[6-(1H-IMIDAZOL-1-YL)-4-PYRIMIDINYL]AMINO}PHENYL)UREA DERIVATIVES AS MCT4 INHIBITORS FOR THE TREATMENT OF CANCER | CHARLES R DREW UNIV OF MEDICINE AND SCIENCE (US) | 2023-09-06 | — | — | EP | disclosed |